Where the real issue lies: Normative conflict between the WTO system and...
The conflict between the WTO system and human rights is typically presented as a technical problem, chiefly attributable to the parallel development of the two regimes. To resolve conflicts between the...
View ArticleHierarchy of norms: the case for the primacy of human rights over WTO law
How World Trade Organization (WTO) rules relate to human rights norms, and whether one takes precedence over the other in the event of conflict remains a subject of contention. This article aims to...
View ArticleRole for the terminal clasp of hiv-1 gp41 glycoprotein in the initiation of...
The binding by HIV-1 gp120 to CD4 and a chemokine receptor activates the membrane fusion glycoprotein, gp41. The fusion function of gp41 involves the refolding of its core into a 6-helix bundle, which...
View ArticleInteraction of human, rat, and mouse immunoglobulin A (IgA) with...
Host survival depends on an effective immune system and pathogen survival on the effectiveness of immune evasion mechanisms. Staphylococcus aureus utilizes a number of molecules to modulate host...
View ArticleAlternative coreceptor requirements for efficient CCR5- and CXCR4-mediated...
Macrophage tropism of human immunodeficiency virus type 1 (HIV-1) is distinct from coreceptor specificity of the viral envelope glycoproteins (Env), but the virus-cell interactions that contribute to...
View ArticleAntibody recognition of cancer-related gangliosides and their mimics...
Modified gangliosides may be overexpressed in certain types of cancer, thus, they are considered a valuable target in cancer immunotherapy. Structural knowledge of their interaction with antibodies is...
View ArticleThe carbohydrate-binding promiscuity of Euonymus europaeus lectin is...
Euonymus europaeus lectin (EEL) is a carbohydrate-binding protein derived from the fruit of the European spindle tree. EEL was first identified for its erythrocyte agglutinating properties and...
View ArticleAllosteric Modulation of the HIV-1 gp120-gp41 Association Site by Adjacent...
The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb)....
View ArticleDistinct patterns of diversity, population structure and evolution in the...
Background: As Plasmodium falciparum and Plasmodium vivax co exist in most malaria endemic regions outside sub-Saharan Africa, malaria control strategies in these areas must target both species in...
View ArticleIdentification of residues involved in NS2 homodimerization and elucidation...
The NS2 protein of hepatitis C virus (HCV) plays a critical role in virus morphogenesis and infectivity. The crystal structure of the C-terminus of the NS2 protein (NS2 Pro) from the H77 strain...
View ArticlePolymorphisms and interspecies differences of the activating and inhibitory...
Little is known of the impact of Fc receptor (FcR) polymorphism in macaques on the binding of human (hu)IgG, and nothing is known of this interaction in the pig-tailed macaque (Macaca nemestrina),...
View ArticleAlexis Wright's fiction as world making
This essay examines Indigenous Australian writer Alexis Wright's novels Plains of Promise (1997) and The Swan Book (2013), alongside debates within world literature. These debates prize open the...
View ArticleCold-induced precipitation of a monoclonal IgM: A negative activation...
Cold-induced precipitation of a monoclonal IgM cryoglobulin isolated from a patient with Waldenström's macroglobulinemia was observed to have a negative activation enthalpy. The rate of the reaction...
View ArticleStructural elements of primary CCR5-using HIV-1 gp120 proteins influencing...
Structure-guided approaches to HIV-1 vaccine design depend on knowledge of the presentation of neutralizing epitopes on gp120, such as the epitope for the broadly neutralizing mAb b12. Here, we...
View ArticleAutoMap: A tool for analyzing protein-ligand recognition using multiple...
Prediction of the protein residues most likely to be involved in ligand recognition is of substantial value in structure-based drug design. Considering multiple ligand binding modes is of potential...
View ArticlePeptide inhibitors of xenoreactive antibodies mimic the interaction profile...
Carbohydrate-antibody interactions mediate many cellular processes and immune responses. Carbohydrates expressed on the surface of cells serve as recognition elements for particular cell types, for...
View ArticleMacrophage-tropic HIV-1 variants from brain demonstrate alterations in the...
BR-derived HIV-1 strains have an exceptional ability to enter macrophages via mechanisms involving their gp120 Env that remain incompletely understood. Here, we used cell-based affinity-profiling...
View ArticlePreservice teachers learning about teaching for conceptual change through...
This study reports on research into the use of Slowmation in a general science methods program in teacher education as a productive way of teaching student teachers how to recognize and respond to...
View Article